klb aav viruses Search Results


klb aav viruses  (Vector Biolabs)
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Vector Biolabs klb aav viruses
a Mice that had been fed a ND or HFD for 12 weeks were treated i.v. for 3 h with 0.1 mg/kg FGF21, and hepatic levels of the indicated proteins were detected by IB (left, n = 3 mice). The ratios of band intensities for the indicated proteins are shown (right) . b Mice were fed a HFD for the times indicated and mRNA levels of <t>Klb,</t> JMJD3, Fgfr1, and Fgfr4 were measured by q-RTPCR ( n = 3 mice). c Mice fed a HFD for 8 weeks were injected with <t>AAV-TBG-KLB</t> or AAV-TBG-GFP. Four weeks later, the mice were treated i.v. with vehicle or 0.1 mg/kg FGF21 for 3 h, and hepatic protein levels of the indicated proteins were detected by IB (n = 2 mice). Source data are provided as a Source Data file. a , b Values are presented as mean ± SD. Statistical significance was measured using the a two-way ANOVA with the Bonferroni or b one-way ANOVA with the Dunnett post-test * P < 0.05, ** P < 0.01, and NS, statistically not significant.
Klb Aav Viruses, supplied by Vector Biolabs, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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a Mice that had been fed a ND or HFD for 12 weeks were treated i.v. for 3 h with 0.1 mg/kg FGF21, and hepatic levels of the indicated proteins were detected by IB (left, n = 3 mice). The ratios of band intensities for the indicated proteins are shown (right) . b Mice were fed a HFD for the times indicated and mRNA levels of Klb, JMJD3, Fgfr1, and Fgfr4 were measured by q-RTPCR ( n = 3 mice). c Mice fed a HFD for 8 weeks were injected with AAV-TBG-KLB or AAV-TBG-GFP. Four weeks later, the mice were treated i.v. with vehicle or 0.1 mg/kg FGF21 for 3 h, and hepatic protein levels of the indicated proteins were detected by IB (n = 2 mice). Source data are provided as a Source Data file. a , b Values are presented as mean ± SD. Statistical significance was measured using the a two-way ANOVA with the Bonferroni or b one-way ANOVA with the Dunnett post-test * P < 0.05, ** P < 0.01, and NS, statistically not significant.

Journal: Nature Communications

Article Title: Fasting-induced FGF21 signaling activates hepatic autophagy and lipid degradation via JMJD3 histone demethylase

doi: 10.1038/s41467-020-14384-z

Figure Lengend Snippet: a Mice that had been fed a ND or HFD for 12 weeks were treated i.v. for 3 h with 0.1 mg/kg FGF21, and hepatic levels of the indicated proteins were detected by IB (left, n = 3 mice). The ratios of band intensities for the indicated proteins are shown (right) . b Mice were fed a HFD for the times indicated and mRNA levels of Klb, JMJD3, Fgfr1, and Fgfr4 were measured by q-RTPCR ( n = 3 mice). c Mice fed a HFD for 8 weeks were injected with AAV-TBG-KLB or AAV-TBG-GFP. Four weeks later, the mice were treated i.v. with vehicle or 0.1 mg/kg FGF21 for 3 h, and hepatic protein levels of the indicated proteins were detected by IB (n = 2 mice). Source data are provided as a Source Data file. a , b Values are presented as mean ± SD. Statistical significance was measured using the a two-way ANOVA with the Bonferroni or b one-way ANOVA with the Dunnett post-test * P < 0.05, ** P < 0.01, and NS, statistically not significant.

Article Snippet: Rapamycin, bafilomycin A 1, WY14643, oleic acid, and inhibitors of ERK and PKA were purchased from Sigma Inc, ON-TARGET plus mouse siRNAs for PPARα (J-040740), CREB1 (J-040959), FOXO1 (J-041127), FGF21 (M-063178-01-0005), and JMJD3 (J-063799) from Dharmacon, Inc, adenoviruses for JMJD3 and shRNA for ATG7 and KLB AAV viruses from Vector Builder, and AAV-TBG-Cre from Vector Biolabs.

Techniques: Reverse Transcription Polymerase Chain Reaction, Injection